Long-term progression of hydroxychloroquine retinopathy off the drug marmor

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  1. VBProject Well-Known Member

    Long-term progression of hydroxychloroquine retinopathy off the drug marmor

    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Oct 16, 2014 Hydroxychloroquine is often prescribed as long-term therapy for many dermatologic indications, and it may have broader benefits e.g. preventing or improving thrombophilia associated with lupus erythematosus, neonatal lupus erythematosus, diabetes in rheumatoid arthritis and other connective tissue diseases, and as adjunctive therapy in some cancers. Furthermore, to show the long-term progression of retinopathy in the whole retina, follow-up examinations should be conducted to document disease progression at the individual level. Regarding disease progression, it cannot be concluded whether Figures 5 and 6 truly indicate a natural progression of HCQ retinopathy, as these were not sequential in time and thus can be a series of different presentations. PURPOSE To characterize the stability or progression of different stages of hydroxychloroquine HCQ retinopathy up to 20 years after stopping the drug. METHODS We reviewed findings from 13 patients with initial HCQ retinopathy classified as early patchy photoreceptor damage, moderate ring of photoreceptor thinning or scotoma, or severe retinal pigment epithelial RPE damage.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Long-term progression of hydroxychloroquine retinopathy off the drug marmor

    HCQ Retinopathy Update 2019 - Acuity Eye Center, Evaluation of Hydroxychloroquine Retinopathy Using Ultra.

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  4. The potential for chloroquine phosphate and hydroxychloroquine sulfate retinopathy to progress after cessation of the drug has long been recognized, 1 - 4 primarily in patients with severe ring scotoma or a visible bull’s-eye lesion in the fundus. Such progression could continue for many years after the drug was stopped.

    • Progression of Hydroxychloroquine Retinopathy - JAMA.
    • Michael Marmor, MD's Profile Stanford Profiles.
    • Effect of Disease Stage on Progression of Hydroxychloroquine..

    IMPORTANCE Hydroxychloroquine sulfate is widely used for the long-term treatment of autoimmune conditions but can cause irreversible toxic retinopathy. Prior estimations of risk were low but were based largely on short-term users or severe retinal toxicity bull's eye maculopathy. Hydroxychloroquine retinopathy primarily involves outer retina photoreceptors. Outer retinal thinning while using HCQ initially involves the parafovea, but becomes diffuse across the macula as damage progresses or after drug cessation. Chloroquine retinopathy, is a form of toxic retinopathy caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. This eye toxicity limits long-term use of the drugs.

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    Hydroxychloroquine - DrugBank Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like chloroquine. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus.

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