Chemotherapy and targeted therapies, including the Bcl-2 inhibitor ABT-737, may induce tumor cell autophagy. Autophagy can promote survival of cancer cells under stress and comprise a pathway of escape from cytotoxic therapies. Hydroxychloroquine class Accidently took next days dose of hydroxychloroquine How effective is plaquenil for rheumatoid arthritis Does hydroxychloroquine Beclin-1 is a protein that in humans is encoded by the BECN1 gene. Beclin-1 is a mammalian ortholog of the yeast autophagy-related gene 6 Atg6 and BEC-1 in the C. elegans nematode. This protein interacts with either BCL-2 or PI3k class III, playing a critical role in the regulation of both autophagy and cell death Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent. Ying Geng, * Latika Kohli, * Barbara J. Klocke, and Kevin A. Roth. Chloroquine CQ, traditionally used as an antimalarial medication, has emerged as a prospective adjunct in tumor therapy. Beclin-1, an autophagy initiating protein was reported to directly interact with HER2. Moreover, this interaction was shown to influence autophagy activity. Additionally, Beclin-1 expression was reported to be lower in HER2 + tumours. In the context of resistance to HER2-targeting treatments, autophagy was reported to be upregulated. These included cell culture analyses of viability and of autophagic and apoptotic pathway induction, as well as in vivo analyses of efficacy in multiple xenograft models. We explored the combination of ABT-737 and chloroquine, an inhibitor of autophagy, in preclinical models of SCLC. Chloroquine and beclin Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs, Chloroquine-induced autophagic vacuole accumulation and. Plaquenil immunosuppressionChloroquine treatment of cellsLorazepam and hydroxychloroquine Chloroquine in Cancer Therapy A Double-Edged Sword of Autophagy Tomonori Kimura, Yoshitsugu Takabatake, Atsushi Takahashi, and Yoshitaka Isaka. Beclin 1 has. Chloroquine in Cancer Therapy A Double-Edged Sword of Autophagy. Swiss Medical Weekly - The role of autophagy in HER2-targeted.. Chloroquine and 3-Methyladenine Attenuates Periodontal.. The production of reactive oxygen species was measured using CM-H2DCFDA staining. A xenograft tumor model of pancreatic cancer was created to determine the efficacy of gambogic acid and chloroquine. Gambogic acid induced the expression of LC3-II and Beclin-1 proteins in pancreatic cancer cells, whereas the expression of P62 showed a decline. Jan 27, 2010 Glioblastoma GBM is a high-grade central nervous system malignancy and despite aggressive treatment strategies, GBM patients have a median survival time of just 1 year. Chloroquine CQ, an antimalarial lysosomotropic agent, has been identified as a potential adjuvant in the treatment regimen of GBMs. Nov 15, 2015 Chloroquine is commonly used to study the role of endosomal acidification in cellular processes 2, 3, such as the signaling of intracellular TLRs. Moreover, Chloroquine inhibits autophagy as it raises the lysosomal pH, which leads to inhibition of both fusion of autophagosome with lysosome and lysosomal protein degradation 4.