She started me on the generic version of Plaquenil at 200 mg. I have had extreme nausea, diarrhea, stomach cramps, and intense vertigo. I began taking it on Thanksgiving day and still experience these side effects. Plasmodium falciparum resistance to chloroquine Chloroquine and brain cancer Liver Enzymes. The liver produces several enzymes involved in metabolism. Among them, the aminotransferases, also called the transaminases, ALT and AST, which function in protein metabolism, have particular diagnostic value, as they become elevated in several diseases, including those of the liver and gallbladder in addition to disorders of other tissues, including the heart and muscle. After gallbladder removal bile function is impaired which can cause digestive problems. It is also common for liver dysfunction to occur after gallbladder removal as extra work is put on the liver. To check liver function we recommend you get an ultrasound scan and/or liver function test. All of these medications can cause damage to the liver and increased liver enzymes. Let your physician know before starting these medications if you have any history of liver disease. Follow your physician’s prescription for these medications and have your liver enzymes tested on a regular basis. She cut my dose in half (100 mg) and that has partially helped the symptoms. A week ago I asked if there was anything we could do and she stated that this was the only treatment pill option. Can plaquenil cause liver problems Allergic reaction to Plaquenil Lupus Forums at The Lupus., Things you must know if you don’t have a gallbladder. Chloroquine g6pd onset It is characterized by yellowing of eyes and skin. Jaundice is not a disease, but a common symptom of several conditions that can be hepatic as well as non-hepatic. When the underlying cause is liver, there is either too much production or accumulation of bilirubin in your body. Warning Signs and Symptoms of The Liver Disease that.. Rheumatoid Arthritis & Elevated Liver Enzymes Healthfully. Will you have Elevated liver enzymes with Plaquenil.. Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Effectively prevents and treats malaria, and treats a certain type of intestinal infection but can cause serious side effects in certain people. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Issues with the immune system may cause attacks on the liver causing Primary biliary cirrhosis; Autoimmune hepatitis; Primary sclerosing cholangitis 1,2 Fatty liver. Alcoholic liver disease ALD-specific early symptoms are abdominal pain, feeling sick, fatigue, feeling unwell, and decrease in appetites. Specific late symptoms are jaundice, swelling of extremities, fever, and itchy skin.