Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Eye toxicity hydroxychloroquine Plaquenil generic coupon Hydroxychloroquine 200 mg If two of the tests are found to show abnormalities, and both are consistent with hydroxychloroquine. toxicity, it means there are definite signs of retinopathy. The degree of retinopathy will be described as ‘mild’, ‘moderate’ or ‘severe’. If the degree of retinopathy is mild and you are. having a good response to the. Time Domain OCT in Hydroxychloroquine Plaquenil Toxicity Time domain OCT does not have the resolution that spectral domain OCT has, making detection of hydroxychloroquine maculopathy by this modality less sensitive. Aug 29, 2014 Several risk factors may increase the likelihood of retinal toxicity from Plaquenil such as, age of greater than 60 years, daily dose more than 6.5 mg/kg; use of the drug more than 5 years, obesity, preexisting retinal disease and, renal or liver failure. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Oct testing in plaquenil macular toxicity Expanded spectral domain-OCT findings in the early detection., Time Domain OCT in Hydroxychloroquine Plaquenil Toxicity. When should prophylactic chloroquine be takenChloroquine mode of action malariaStopping plaquenil headachesPlaquenil drug guide Plaquenil Toxicity Condition/keywords plaquenil toxicity, hydroxychloroquine toxicity Imaging device Optical coherence tomography system Description SD-OCT scan from a 44-year-old woman with bilateral plaquenil toxicity. There is damage visible in the outer retina in a perifoveal distribution. Related files Plaquenil Toxicity - Retina Image Bank. The Risk of Retinal Toxicity with Plaquenil. Plaquenil Toxicity Screening - Retina Group of New York. Nov 01, 2015 OBJECTIVE TESTS Spectral-domain OCT. Typically, cases of HCQ toxicity may demonstrate parafoveal thinning and loss of the ellipsoid zone, with preservation of the foveal architecture — creating the “flying saucer” shape Figures 1 and 2. The goal for Plaquenil Screening to detect toxicity early and stop the medication as soon as possible if present. Functional test that focus on central field sensitivity may pick up early toxicity. Early structural changes may be difficult to detect and high resolution optical coherence tomography OCT and fundus autofluorescence are very useful in detecting subtle changes. Optometrists and ophthalmologists need to be aware of the American Academy of Ophthalmology’s 2011 guidelines on screening for retinal toxicity associated with plaquenil. Newer studies have preferred practice protocols be changed to using spectral-domain OCT technology as the main screening device for detection of early retinal changes in plaquenil toxicity.