Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking chloroquine: Incidence not known Some side effects of chloroquine may occur that usually do not need medical attention. Plaquenil retinopathy pathogenesis Pepto bismol and plaquenil Borden MB, Parke AL 2001 Antimalarial drugs in systemic lupus erythematosus use in pregnancy. Drug Saf 55–1063 PubMed CrossRef Google Scholar Boström H, Moretti A, Whitehouse M 1963 Studies of the biochemistry of heart valves. On the biosynthesis of mucopolysaccharides in bovine heart valves. Seizures as a rare adverse effect of chloroquine therapy in systemic lupus erythematosus patients a case report and literature survey Piotr Krzeminski, 1 Aleksandra Lesiak, 2 and Joanna Narbutt 2 Exacerbations of bipolar disorder triggered by chloroquine in systemic lupus erythematosus—a case report J Bogaczewicz, T Sobów, A Bogaczewicz, E Robak, P Bienkowski, A Sysa-Jędrzejowska, and A Woźniacka Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Chloroquine systemic lupus erythematosus Systemic Lupus Erythematosus SLE CDC, Seizures as a rare adverse effect of chloroquine therapy in. Can you take flexeril with plaquenilHydroxychloroquine keratopathyFinasteride vs plaquenil Symptoms of systemic lupus erythematosus SLE, often referred to as simply lupus can be quite different, because there are different types of lupus, and not all affected people show the same symptoms. Nevertheless, there are certain symptoms and signs commonly associated with the condition. The signs and symptoms of lupus are sometimes described in terms of the classic triad of Systemic Lupus Erythematosus SLE Symptoms, Signs.. Exacerbations of bipolar disorder triggered by chloroquine.. Controlled trial with chloroquine diphosphate in systemic.. Fortunately, it was discovered these drugs often are helpful in the treatment of various rheumatic diseases, particularly systemic lupus erythematosus SLE or "Lupus" and rheumatoid arthritis. Although chloroquine is sometimes used, the preferred antimalarial drug is hydroxychloroquine due to its greater safety. These drugs are not painkillers. Several cases of hypopigmentation of the skin have been reported. Most of the patients described were African or of African descent with dark skin who had been exposed to the sun. One was a Hispanic patient who developed vitiligo-like skin depigmentation after 1 month of chloroquine therapy for cutaneous lupus erythematosus. The skin rapidly repigmented after discontinuation of chloroquine therapy. A variety of antimalarial medications have been shown to be effective for systemic rheumatic diseases since quinine was first used to treat systemic lupus erythematosus SLE more than 100 years ago. Three of these drugs are now primarily used due to their safety profile. Chloroquine and hydroxychloroquine HCQ are 4-aminoquinoline derivatives.