I also have been having unexplained swelling of my tongue, wrists, bottom of my feet and lip, spreading up in my cheek. Now my wife and i are very concerned and planning on going to see my doctor soon. I know it isn't allergies because I have kept a diary and there is no pattern as in your case I too would like some help in clarifying it. Dose of chloroquine for malaria treatment Can plaquenil affect mcv Get emergency medical help if you have signs of an allergic reaction to Plaquenil hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking Plaquenil and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Call your doctor at once if you have It actually wasn't a sore or ulcer at all, but a cyst or mucocele cause by a blockage of minor salivary glands in my lip. The salivary glands are involved in the inflammatory process of Sjogren's syndrome, which is why many of us with Sjogren's have dry mouths and sometimes painful and enlarged salivary glands. Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, and sex organs. loss of hearing. lower back or side pain. noisy breathing. painful or difficult urination. red irritated eyes. red skin lesions, often with a purple center. severe mood or mental changes. sore throat sores, ulcers, or white spots on the lips or in the mouth I have tried to put all of this on food, detergent, allergies, etc.. Currently as I'm writing this am having the same symptoms you describe under my feet, it started about 4-5 months ago, were swelling of the lips, tongue and side of the mouth swells up, and most recently started to get the swelling under my feet with the same description you noted, also my hand and my wrist, all these caused an itching feeling and felt very warm to touch and is difficult to walk on. I ate a chocolate apricot cake, something I have never had. The same exact thing that you have described has happened to me and much more regularly recently. my wife and i thought it maybe caused due to an allergic reaction, i did go to en allergist and after various tests he indicated that i am not allergic to anything. My foot had this crazy itch (left foot) and then I was walking and it felt like the outside of my foot had like gum or something stuck to the bottom of it. I have been told it is stress, but I don't feel stressed. Plaquenil lip swelling Lip swelling in Systemic lupus erythematosus - eHealthMe, Giving 'em Lip - Sjogren's, Salivary Glands, and More Fun Rheumatoid arthirtis methrotrexate therapy hydroxychloroquine monotherapyMethylene blue falciparum chloroquine reversalPlaquenil as it affects the eyes symptoms What are the possible side effects of hydroxychloroquine Plaquenil, Plaquenil Sulfate, Quineprox? Get emergency medical help if you have signs of an allergic reaction hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Plaquenil Hydroxychloroquine Side effects, Images, Uses, Dosage.. Plaquenil Side Effects - GoodRx. Sudden unexplained swelling, hands, feet, lip, wrists.. Usually not Chapped lips is often due to lip eczema dryness, irritation, cracking, peeling. Too much sun, wind, or water exposure; excessive washing; repeated lip licking; and allergies to lip balm or lipstick ingredients are common causes. Allergic reactions hives, etc. can chap lips. Plaquenil Hydroxychloroquine belongs to a group of medications known as anti-inflammatories and antimalarials. It is used alone or in combination with other anti-arthritic medications to treat rheumatoid arthritis. It helps to reduce pain, stiffness, and swelling in joints. Swollen lips are caused by underlying inflammation or a buildup of fluid under the skin of your lips. Many things can cause swollen lips, from minor skin conditions to severe allergic reactions.