It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. What class of drug is hydroxychloroquine sulfate Dosage of plaquenil for sjogren& 39 SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. It can also be used pretty much indefinitely, as long as there is no sign of eye problems. Occasionally, someone will really have no measurable response to Plaquenil, but most docs will allow at least 6 months for that decision to be made because the lag time from taking the medicine to its effectiveness is so long. Plaquenil is not deposited into fat,” he explains. “That is why it is recommended that we go by ideal body weight, or IBW—taking into account lean body mass more so than any extra fat mass in people who are overweight.” The American Association of Ophthalmology recommends using the "Devine formula" to determine ideal body weight. Hydroxychloroquine is often taken in combination with other drugs such as methotrexate. Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. It may be as long as 12 weeks before you notice the benefits. Why does plaquenil take so long to work How long does it take for plaquenil to work - Answers, PLAQUENIL" Osteoarthritis Community - Support Group Can i take plaquenil with hydroxyzineHydroxychloroquine dosage for osteoarthritisWhen to switch from plaquenil to methotrexate Hydroxychloroquine doesn’t work immediately. It may be 12 weeks or longer before you notice any benefit. Because it's a long-term treatment it's important to keep taking hydroxychloroquine unless you have severe side-effects even if it doesn't seem to be working at first; even when your symptoms improve to help keep the disease under. Hydroxychloroquine Side-effects, uses, time to work. Protecting your eyesight when taking Plaquenil Lupus.. Can you take plaquenil hydroxychloroquine if you have psoriasis.. The usual starting dose of Plaquenil is 200 mg twice a day or 400 mg once a day, administered orally, in people weighing 80 kg or more. The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs. It's important to watch for possible side effects and toxicity. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Mar 24, 2011 Had headaches with the plaquenil so went to the sulfar and predisone. Sulfar was a waste of time and since I had a little help from the plaquenil he switched me back to that with pain meds for the headaches and body. Recently i went back for app. and plaquenil had stopped doing anything so he added the methotrexate to it. I did not want to take it.