Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Antimalarial drugs chloroquine and primaquine Chloroquine synthesis slideshare Why is the drug hydroxychloroquine Hydroxychloroquine Plaquenil may be helpful for skin lesions and elevated blood-calcium levels. Tumor necrosis factor-alpha TNF-alpha inhibitors. These medications are commonly used to treat the inflammation associated with rheumatoid arthritis. They can also be helpful in treating sarcoidosis that hasn't responded to other treatments. Rheumatoid Arthritis. The action of hydroxychloroquine is cumulative and may require weeks to months to achieve the maximum therapeutic effect see CLINICAL PHARMACOLOGY. Initial adult dosage 400 mg to 600 mg 310 to 465 mg base daily, administered as a single daily dose or in two divided doses. Neutropenia is a decrease in circulating neutrophils in the nonmarginal pool, which constitutes 4-5% of total body neutrophil stores. Most of the neutrophils are contained in the bone marrow, either as mitotically active one third or postmitotic mature cells two thirds. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Neutropenia hydroxychloroquine HYDROXYCHLOROQUINE SULFATE Drug BNF, Plaquenil - FDA prescribing information, side effects and uses Hydroxychloroquine and lexaproPlaquenil side effects fluid retentionPlaquenil withdrawalWhat is hydroxychloroquine sulfate used to treat Hydroxychloroquine oral tablet is available as a brand-name drug and a generic drug. Brand name Plaquenil. Hydroxychloroquine comes only as a tablet you take by mouth. Hydroxychloroquine is used to treat malaria, lupus erythematosus, and rheumatoid arthritis. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Neutropenia Practice Essentials, Background, Pathophysiology. Hydroxychloroquine Plaquenil Side Effects & Dosage for.. This article is a review of different management strategies for the hematological manifestations of systemic lupus erythematosus SLE, the strategies include immunosuppressive drugs, some noval therapies and B-cell depletion for refractory thrombocytopenia in patients with SLE and in antiphospholipid antibody syndrome associated with SLE. A case of hydroxychloroquine-induced agranulocytosis in a patient with discoid lupus erythematosus is reported. The patient had previously received chloroquine therapy for several months. Leukopenia preceded the appearance of agranulocytosis, and persisted for six weeks following clinical recovery. Hydroxychloroquine HCQ HCQ addition in the treatment of patients with SLE, APS either primary or secondary is associated with decrease aPL titers and decrease risk of thrombosis 53. HCQ inhibits the aPL-induced expression of platelet GPIIb/IIIa receptor platelet activation in a dose-dependent fashion 54.