It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Chloroquine proguanil dose Months for hydroxychloroquine to work on joints All the rest of the DMARDS Methotrexate, Plaquenil - Hydroxycholoquine, Arava - Leflunomide, Sulfazalazine ETC will all take 6 to 12 weeks to make any signifigant dent in RA symptoms - they are NOT FAST ACTING. They do alter the disease course and slow damage Prednisone doesn't do that. Sorry to hear that you are having a lot of pain with your RA. I have lupus which mainly affects my joints and skin. I have been taking hydroxychloroquine which is the generic of plaquenil for the past three years. My rheumy recently added Imuran instead of methotrexate. Plaquenil hydroxychloroquine takes up to 3 months to begin working. OBJECTIVE To examine the bioavailability of methotrexate MTX in the presence of hydroxychloroquine HCQ, and vice versa, to determine a possible pharmacokinetic explanation for the observation that combination treatment of rheumatoid arthritis with MTX and HCQ has been shown, clinically, to be more potent than MTX used alone. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Plaquenil and methotrexate together Compare Methotrexate vs Plaquenil for Lupus., Which would you pick and why? - Plaquenil or Methotrexate Chloroquine dose in liver abscess Learn about drug interactions between hydroxychloroquine oral and methotrexate sodium oral and use the RxList drug interaction checker to check drug combinations. Drugs A-Z Pill Identifier Supplements Symptom Checker Diseases Dictionary Media Hydroxychloroquine oral and methotrexate sodium oral Drug.. Combination therapy with methotrexate and hydroxychloroquine.. Does anyone take methotrexate and hydroxychloroquine.. Adults. 200 mg 155 mg base to 400 mg 310 mg base PO per day, administered as a single dose or in 2 divided doses. Antimalarials and/or glucocorticoids are of benefit and may be used for the treatment of SLE without major organ manifestations; however, judicious use of hydroxychloroquine is recommended. Optimal use of disease‐modifying antirheumatic drugs DMARDs in rheumatoid arthritis is vital if progression of disease is to be reduced. Methotrexate MTX and sulfasalazine SASP are widely used inexpensive DMARDs, recently often combined despite no firm evidence of benefit from previous studies. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others.