Quinacrine and hydroxychloroquine lupus panniculitis

Discussion in 'Chloroquine 250' started by Zema, 06-Mar-2020.

  1. enc Well-Known Member

    Quinacrine and hydroxychloroquine lupus panniculitis


    Detailed information on how Wiley uses cookies can be found in our Privacy Policy. Lipomembranous panniculitis is a morphologic description, not a specific disease entity.

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    Lupus panniculitis is a rare type of chronic cutaneous lupus accounting for only 1-3% of patients with cutaneous lupus. The association with systemic lupus ranges from 10-42% and most patients are women in their late 30s and early 40s. Subcutaneous nodules usually occur on the shoulders, proximal extremities, buttocks and face. Lupus panniculitis often responds to treatment with antimalarials, such as hydroxychloroquine 200 mg once or twice a day. Some cases respond to a combination of antimalarials for example, hydroxychloroquine 200 mg and quinacrine 100 mg daily when monotherapy is ineffective. Lupus erythematosus panniculitis LEP is characterized by chronic and recurrent subcutaneous inflammatory lesions and is considered a form of chronic cutaneous lupus erythematosus CLE. Clinically, LEP appears as erythematous, deeply indurated, tender plaques and nodules.

    The finding of lipomembranes in a panniculitis is diagnostically relevant, however, because it suggests a possible ischemic etiology. Lipomembranes have been described in adipose tissue in adrenal leukodystrophy, stasis dermatitis, peripheral vascular arterial disease leading to ischemia, diabetes mellitus, lupus erythematosus, nodulocystic fat necrosis, and adipose tissue after trauma from surgical procedures nearby.

    Quinacrine and hydroxychloroquine lupus panniculitis

    Effectiveness of Quinacrine Mepacrine in Photosensitive., Lupus panniculitis lupus profundus - eScholarship

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  3. Panniculitis secondary to other connective tissue diseases such as morphea, dermatomyositis, and overlap syndrome can sometimes be clinically and histologically indistinguishable from lupus panniculitis.

    • Lupus Erythematosus Panniculitis - an overview..
    • Lupus profundus Panniculitis Lupus Erythematosus..
    • Lupus panniculitis SpringerLink.

    Systemic lupus erythematosus is a chronic, multisystem, inflammatory disorder of autoimmune etiology, occurring predominantly in young women. Common manifestations may include arthralgias and arthritis, Raynaud syndrome, malar and other rashes, pleuritis or pericarditis, renal or central nervous system involvement, and hematologic cytopenias. Hydroxychloroquine Plaquenil is the most commonly prescribed because it is generally believed to cause fewer side effects; chloroquine Aralen has a reputation for more serious side effects, but it may be prescribed in situations where hydroxychloroquine cannot be used. Quinacrine Atabrine is another alternative, but it is prescribed less often because it can sometimes cause a yellow discoloration of the skin. In 1956, the U. S. Food and Drug Administration approved HCQ for symptoms of lupus and rheumatoid arthritis, particularly skin inflammation, hair loss, mouth sores, fatigue, and joint pain. Dosing Hydroxychloroquine is generally prescribed at a daily dose of 6.5 milligrams or less per kilogram of body weight.

     
  4. beLka_voo Moderator

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. The Efficacy of Artesunate, Chloroquine, Doxycycline. Chloroquine Phosphate Monograph for Professionals - Chloroquine Oral Uses, Side Effects, Interactions.
     
  5. grandia User

    500 mg chloroquine phosphate (300 mg base) orally on the same day each week Comments: -If possible, suppressive therapy should start 2 weeks prior to exposure; if unable to start 2 weeks before exposure, an initial loading dose of 1 g chloroquine phosphate (600 mg base) may be taken orally in 2 divided doses, 6 hours apart. Chloroquine Suppliers USA Chloroquine drug Britannica Where To Buy Chloroquine Phosphate
     
  6. OWOX New Member

    Hydroxychloroquine Indications, Side Effects, Warnings. May 24, 2019 Low blood cell counts have happened with hydroxychloroquine. If blood cell counts get very low, this can lead to bleeding problems, infections, or anemia. Call your doctor right away if you have signs of infection like fever, chills, or sore throat; any unexplained bruising or bleeding; or if you feel very tired or weak.

    Symptoms of a Low White Blood Count Healthfully
     
  7. arktom Guest

    Chloroquine Phosphate Prices, Coupons & Savings Tips - GoodRx CHLOROQUINE is used to treat or prevent malaria infections. It is also used to treat amebiasis. The lowest GoodRx price for the most common version of chloroquine phosphate is around .38, 84% off the average retail price of 4.50.

    Chloroquine Oral Route Proper Use - Mayo Clinic