Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. Synthroid and plaquenil Taking hydroxychloroquine and sulfasalazine together side effects What does hydroxychloroquine treat The recommended adult dosage is 200 to 400 mg 155 to 310 mg base daily, administered as a single daily dose or in two divided doses. Doses above 400 mg a day are not recommended. The incidence of retinopathy has been reported to be higher when this maintenance dose is exceeded. Mg PO daily in a single or divided dose tablets are 200 mg. To reduce the risk of retinopathy, do not exceed 5 mg/kg/day or 400 mg PO daily. DOSE ADJUSTMENT. Hydroxychloroquine is generally considered to be the safest DMARD, and a “go to” drug for pregnancy. Hydroxychloroquine Retinopathy Still Alive and Well. May 16, 2011 • By Michael F. Marmor, MD. Daily Dose. The new AAO recommendations focus more on the duration of treatment rather than a daily dose but emphasize that overdosage is dangerous. 2 Most patients receive two tablets 400 mg per day, which is fine for women taller than 5 ft. While early toxicity may be asymtomatic, patients with more advanced stage of toxicity may complain of color vision changes or paracentral scotomas. Its toxic effects on the retina are seen in the macula. Plaquenil daily dose to minimize retinopathy Hydroxychloroquine And Chloroquine Screening 2016 AAO., Hydroxychloroquine Plaquenil RheumTutor Best time to take hydroxychloroquine Hydroxychloroquine sulfate HCQ, Plaquenil is an analogue of chloroquine CQ, an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy. Retinal toxicity associated with chronic exposure to hydroxychloroquine.. Hydroxychloroquine Retinopathy Still Alive and Well - The.. Hydroxychloroquine retinopathy Eye. Oct 23, 2006 She said she was treated with 200mg to 400mg of Plaquenil hydroxychloroquine sulfate, Sanofi-Synthelabo per day for her lupus 4.4mg/kg to 8.8 mg/kg per day for two years with a cumulative dose of 276g. The patient said she was also prescribed prednisone for her lupus; the dose had been tapered from 5mg/day to 1mg/day. Despite the fact that 1 there may be some gray areas in Plaquenil dosage calculations and 2 daily dosage is not the only risk factor, it is a risk factor that the eye care specialist can assess. Again, the calculations are not especially difficult, but I hope I can make them a little easier for the busy practitioner. Hydroxychloroquine is generally prescribed at a daily dose of 6.5 milligrams or less per kilogram of body weight. Using this formula, the dosage for a 150-pound person would be 443 mg/day, as one kilogram equals 2.2 pounds. Because HCQ is formulated as a 200 mg tablet, many people taking it for lupus will take two pills per day.