Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Why would you take hydroxychloroquine and mycophenolate Taking two plaquenil instead of 1.5 Mar 07, 2012 I want to believe in my doctor but I don't feel like either one of them bothered to really look into my concern. I think I will just stop the plaquenil and see if I get any relief and I will let him know what I have decided. I am wondering how long it might take for the drug to leave my system so I can see if this is the problem. Hydroxychloroquine doesn’t work immediately. It may be 12 weeks or longer before you notice any benefit. Because it's a long-term treatment it's important to keep taking hydroxychloroquine unless you have severe side-effects even if it doesn't seem to be working at first; even when your symptoms improve to help keep the disease under. Hello kelpie21, It can be a hard road, can't it? Hydroxychloroquine does take a while to take effect. Arthritis UK gives a figure of around 12 weeks, whilst the American College of Rheumatology says, "symptoms can start to improve after 1-2 months, but it may take up to 6 months before the full benefits are felt". Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. How long before plaquenil works How long before pilocarpine works? - Sjogren's World, Hydroxychloroquine Side-effects, uses, time to work Chloroquine hpvOct en face retina mesaurements plaquenilChloroquine diphosphate and phosphate Oct 12, 2009 As I thought about it, I realized that many other small activities that had hurt before were no longer so painful. I had that same experience of having to stop taking it for a while, and the joint aches returned very quickly. The fatigue is better on the Plaquenil, but it doesn't take much for me to overdo it. I really have to pace myself. Plaquenil - How long to take effect?. How long until Hydroxychloroquine takes effect - LUPUS UK. Hydroxychloroquine Plaquenil. How long did Plaquenil take to work for you? My Dr said it would take 3 months! However, I read that it took less time for some people. I know I've asked this question before, but with so many new people and so much time that's passed, I thought I'd ask again. How long did it take for Plaquenil to become effective for you? Meaning, when did you start to feel some relief from your lupus symptoms after you started taking. Jan 29, 2007 Irene, I read your post and it sounds like something I have been through before. I have been on Plaquenil for a long time now and just last summer I found out how sensitive it makes your skin in the sun.