Flying saucer sign plaquenil

Discussion in 'Chloroquine' started by machete, 23-Feb-2020.

  1. SeoWork User

    Flying saucer sign plaquenil


    To characterize structural changes of HCQ retinopathy with SD-OCT after drug cessation. Setting: Private practice and academic institution. Patient Population: Patients at New England Eye Center and Ophthalmic Consultants of Boston in Boston, MA diagnosed with HCQ retinopathy and followed after drug cessation.

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    Patient 2 was found to have a completely normal fundus examination. Fluorescein angiography shows parafoveal hyperfluorescence, and autofluorescence shows a minimal decrease in signal in the same region. In both patients the SD-OCT shows disruption of the ellipsoid zone in parafoveal region flying saucer sign. SD-OCT is capable of detecting characteristic macular changes of HCQ toxicity. These typical macular abnormalities include loss of the parafoveal ellipsoid zone EZ, parafoveal thinning of the outer nuclear layer ONL and inner plexiform layer IPL, the “flying saucersign, and peripapillary nerve fiber layer thinning 12–14. Few reports have examined progression of changes in SD-OCT appearance after drug cessation. Sign/Symptoms. Ocular manifestations of hydroxychloroquine include corneal verticillata and retinal toxicity. Verticillata are cornea deposits of salts within the corneal epithelium. This condition does not cause symptoms and is reversible with cessation of the medication.

    Main Outcome Measures: SD-OCT findings suggestive of HCQ retinopathy before parafoveal ellipsoid disruption. Retrospective clinical data review by the Boston Image Reading Center.

    Flying saucer sign plaquenil

    Comparison of Screening Procedures in Hydroxychloroquine Toxicity, Expanded spectral domain-OCT findings in the early detection.

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  5. kuzman Guest

    Discontinued Plaquenil.other options? The alternative to Plaquenil is a slightly different anti malarial called Quinacrine. Plaquenil replaced Quinacrine formerly called Atabrine for anti malarial prophylaxis so now the Quinacrine has to be made up into pills or gel capsules by a compounding pharmacy. If you google you will find details of compounding pharmacies.

    Is there a drug that I can take to replace plaquenil?