Plaquenil is less toxic than chloroquine; however, long-term use of either drug can result in macular toxicity, leading to devastating irreversible vision loss. The mechanism of this toxicity is not clearly understood, though it is believed that the drug molecule binds to melanin in the retinal pigment epithelium (RPE). Plaquenil w o maculopathy Hydroxychloroquine weight loss Plaquenil skin issues Plaquenil hydroxychloroquine sulfate, Sanofi-Aventis and the less-used chloroquine are antimalarial drugs with anti-inflammatory properties that are used for the management of a spectrum of inflammatory conditions. A retrospective cohort studyof 127 patients with RA who were undergoing various orthopedic procedures found that there were no differences in surgical site infections but more cases of wound dehiscence in patients who continued on the drugs. "Hydroxychloroquine or Plaquenil is felt to be safe during the preoperative period. Hydroxychloroquine is a less commonly utilized disease modifying anti-rheumatic medication. It is an anti-malarial medication. There is no indication that Plaquenil requires discontinuation in the perioperative period. In Conclusion. The effect of disease modifying agents on surgical outcome is difficult to assess. Binding of the drug to melanin in the RPE contributes to, or prolongs, its toxic effects. This leads to disruption and damage to the photoreceptors and outer nuclear and plexiform layer, sparing the foveal center and resulting in the “bull’s eye” appearance in the late stage of the disease. Plaquenil and procedures My Take on New Ocular Screening Guidelines for Plaquenil., Hold the immunomodulators for surgery? Maybe yes, maybe no. How was chloroquine discoveredDo you have to be weaned off of plaquenil Revised 10/2011 DAILY MEDICATION USE AND YOUR UPCOMING SURGERY PLEASE take time to thoroughly read this information. It is VERY IMPORTANT for you to know what medications you are taking and to understand what to do about your medications as your surgery date approaches. DAILY MEDICATION USE AND YOUR UPCOMING SURGERY. A Guide To Perioperative Management Of The Rheumatoid Patient.. New Plaquenil Guidelines. Jun 09, 2006 Rheumatoid arthritis RA, the most common form of inflammatory arthritis, can lead to significant pain, disability, and deformity, and is a multisystem autoimmune disorder. The hallmark of this disease, erosive joint destruction, results from unchecked synovial inflammation, which can damage articular cartilage and bone, with resultant loss of joint function. Plaquenil, hydroxychloroquine HCQ, is an anti-malarial medication that has been proven to be useful in the treatment of patients with rheumatoid arthritis RA, systemic lupus erythematosus SLE and other inflammatory and autoimmune diseases. Please help, my sister has sle, she has been under control with plaquenil for 15 years, she recently had surgery on both eyes, one was retinal detachment surg the other a minor lasik like procedure, ever since surgery she has been completely blind in both eyes, her retina has detached again and she is scheduled to have surgery again in 2 days.