Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Flying saucer sign plaquenil Plaquenil hyperpigmentation histology Hydroxychloroquine method of action arthritis Hydroxychloroquine mechanism of action. Hydroxychloroquine is both an antimalarial drug and a disease-modifying anti-rheumatic drug DMARD. As an antimalarial drug, hydroxychloroquine has been shown to accumulate in malaria parasite lysosomes, increasing the pH. Side Effects. Drug information provided by IBM Micromedex Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some viral infections. Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil drug action Plaquenil hydroxychloroquine sulfate dose, indications., Hydroxychloroquine Oral Route Side Effects - Mayo Clinic Retinal thickness changes plaquenil toxicityHydroxychloroquine for early rheumatoid arthritis reviewsMethotrexate and plaquenilHydroxychloroquine sulfate advers reactions Mechanism of action. Drugs that prolong QT interval and other arrhythmogenic drugs PLAQUENIL prolongs the QT interval and should not be administered with other drugs that have the potential to induce cardiac arrhythmias. Also, there may be an increased risk of inducing ventricular arrhythmias if PLAQUENIL is used concomitantly with other. Plaquenil Concordia Pharmaceuticals Inc. FDA Package Insert. Effects of chloroquine on viral infections an old drug.. Hydroxychloroquine Uses, Dosage & Side Effects -. The action of hydroxychloroquine is cumulative and may require weeks to months to achieve the maximum therapeutic effect see CLINICAL PHARMACOLOGY. Initial adult dosage 400 mg to 600 mg 310 to 465 mg base daily, administered as a single daily dose or in two divided doses. The exact mechanism of action for hydroxychloroquine and another antimalarial drug chloroquine in RA is not known, but researchers think these drugs decrease production of a number of different chemicals that are important to the immune response. 3. What are the possible side effects of hydroxychloroquine? Hydroxychloroquine is an antimalarial agent that has been used in systemic lupus erythematosus and rheumatoid arthritis treatment for many years. Recently, novel mechanisms of action have been proposed, thereby broadening the therapeutic perspective of this medication.