Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. When is plaquenil used Is plaquenil used to Hydroxychloroquine is a DMARD. The brand name is Plaquenil. What does Plaquenil do? Plaquenil relieves pain and swelling and prevents damage to joints. How long does Plaquenil take to work? Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. Ok I'll admit I'm impatient to feel better and get on with my life. My question is, how long does it take for plaquenil to make an impact? And does it really help the fatigue? That's my biggest issue. I've been on it for about three and a half weeks. Thanks! Danni My question is for those that have taken Plaquenil/Hydroxychloroquine. How long did it take for it to remove symptoms in your personal experience? I know I've read it can take up to 6 months but what I'm wondering is, do you just wake up one day and find it's kicked in 6 months down the road or more likely, it starts to work slowly over 6 months? Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. How long does it take for plaquenil to kick in How long does it take for plaquenil to leave your system?, When does the plaquenil kick in? DailyStrength Plaquenil enlarged spleenPlaquenil immunosuppression Hi - I just started Plaquenil 400 mg a day two week ago and I started feeling less achy and tired a few days ago. Is it possible for it to work quicker in some people? I've heard it can take months, but I must say that I haven't felt like this since I was a kid - not achy or stiff. Has anyone had a similar Immune & Autoimmune - Lupus Plaquenil - Can It Work Quickly?. How long did Plaquenil/Hydroxychloroquine take? DailyStrength. Plaquenil - time to kick in? rheumatoid. By the time I recognize that I'm getting a flare I think because I was so sick for so long I've learned to ignore it until it's too late and take my first six-pill dose of a medrol pack, it takes a good 24 hours for me to get relief. But I do automatically feel better immediately because I know relief is coming! She said we could try Plaquenil - a milder drug. I was told it takes two months before patients feel any improvement, it took little less for the drug to kick in. Now, it's been a year - I have no flares, no pain and no side effects I can think of. I take one pill in the morning, one in the evening. This drug works well for me." Yep, I was just like you the first time I was taking Plaquenil. "Hurry up, show me". Well, I got really upset about 5 1/2 months into it and stopped taking it. I thought, "If this isn't going help, I am not going to take it". Well, about 2 weeks into my "stop" program, I suddenly realized it was helping me.