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    Options for treatment of tinnitus include selective serotonin reuptake inhibitors (SSRIs); however in rare instances this symptom may occur as a side effect of this class of medications. A 50-year-old woman developed bilateral tinnitus after several weeks of being treated with sertraline 50 mg. Cochlear input is processed through complex interactions between serotonergic, glutamatergic, and GABAergic neurotransmitter systems. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Serotonin is involved in filtering of auditory stimuli. She had been on a long-standing daily dose of aspirin 325 mg which had been discontinued shortly before starting sertraline. Shortly after discontinuation of the medication, her tinnitus subsided completely. Tinnitus is a rare side effect of sertraline and may be related to particular distribution of serotonin receptor subtypes within the auditory system, and serotonergic agents may reinforce or desensitize the activity of different receptors. Also, there may be a priming effect of salicylate agents on the auditory system, predisposing particular patients to be more sensitive to how auditory stimuli are processed. Serotonin has a role in the filtering of auditory input [1], allowing for appropriate disregarding of trivial sensory input [2], and the development of tinnitus may reflect a disturbance in this function [2]. Serotonergic receptors have been described in the cochlea, originating mainly from the dorsal region of the superior olivary complex [3], and this neurotransmitter seems to have a close correlation with GABAergic and glutamatergic input into the cochlea. Ocular Effects of Antidepressants 2016 October vol 23. - WA Health azithromycin 250 mg tablet Life zoloft reviews - Krti2016 Cost-utility analysis of vortioxetine versus agomelatine, bupropion.
     
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