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    Please make sure that Javascript and cookies are enabled on your browser and that you are not blocking them from loading. Reviewed by health care specialists at UCSF Medical Center. This information is for educational purposes only and is not intended to replace the advice of your doctor or health care provider. We encourage you to discuss with your doctor any questions or concerns you may have.

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    Accepted for publication 17 February 2017 Published Volume 20 Pages 1481—1488 DOI https://doi.org/10.2147/DDDT. S131670 Checked for plagiarism Yes Review by Single-blind Peer reviewers approved by Dr Rasika Samarasinghe Peer reviewer comments 2 Editor who approved publication: Professor Manfred Ogris Ph D School in Experimental Medicine, University of Pavia, Pavia, Italy Purpose: The purpose of this study is to evaluate, in a randomized clinical trial, the effects of metformin immediate release (IR) compared with metformin extended release (XR) on the gastrointestinal tolerability and glycemic control. Materials and methods: We enrolled 253 Caucasian patients with type 2 diabetes not well controlled by diet (glycated hemoglobin [Hb A, fasting and postprandial glucose, fasting plasma insulin (FPI) and homeostasis model assessment insulin resistance (HOMA-IR), lipid profile, and levels of some adipocytokines, including tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hs-CRP), visfatin, and vaspin. Moreover, at the baseline and after 6 months, we administered patients some validated questionnaires to assess patients’ satisfaction toward treatments. Results: After 6 months, both formulations gave a similar reduction in body weight and body mass index (BMI); however, metformin XR gave a greater improvement in glycemic control, FPI, and HOMA-IR, compared with both baseline and metformin IR. A reduction in total cholesterol (TC) and low-density lipoprotein (LDL) cholesterol was observed with metformin XR compared with IR. Levels of TNF-α, hs-CRP, and vaspin were reduced by metformin XR but not by the IR formulation. Conclusion: Metformin XR formulation seems to be more effective than metformin IR in improving glyco-metabolic control, lipid profile, and levels of some adipocytokines in patients with type 2 diabetes mellitus. Metformin Hydrochloride Extended-Release Tablets 500 mg - Lupin. cialis pdf Comparison of conventional and sustained-release formulation of. Metformin XR APOTEX Extended release tablets - au
     
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