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    Вспомогательные вещества: целлюлоза микрокристаллическая - 62.632 мг, кальция гидрофосфат - 20.878 мг, натрия кроскармеллоза - 6 мг, магния стеарат - 2.4 мг. Силденафил не влиял на сердечный выброс и не ухудшал кровоток в стенозированных коронарных артериях. Состав пленочной оболочки: опадрай белый II OY-LS-28914 (гипромеллоза, титана диоксид, лактозы моногидрат, триацетин) - 3 мг, опадрай прозрачный YS-2-19114-A (гипромеллоза, триацетин) - 0.9 мг. - блистеры из ПВХ/алюминиевой фольги (6) - пачки картонные с контролем первого вскрытия. У некоторых пациентов через 1 ч после приема силденафила в дозе 100 мг с помощью теста Фансворса-Мунселя 100 выявлено легкое и преходящее нарушение способности цветовосприятия (синего/зеленого цветов); через 2 ч после приема препарата эти изменения исчезали. Селективный ингибитор циклогуанозинмонофосфат (ц ГМФ)-специфической ФДЭ5. У пациентов с легочной гипертензией (ЛГ) прием силденафила приводит к расширению сосудов легких и, в меньшей степени, других сосудов. Его активность в отношении ФДЭ5 превосходит активность в отношении других известных изоферментов фосфодиэстеразы: ФДЭ6, участвующей в передаче светового сигнала в сетчатой оболочке глаза - в 10 раз; ФДЭ1 - в 80 раз; ФДЭ2, ФДЭ4, ФДЭ7-ФДЭ11 - более чем в 700 раз. После приема силденафила в дозе 80 мг 3 раза/сут у здоровых мужчин-добровольцев отмечалось максимальное снижение систолического и диастолического АД в положении лежа в среднем на 9.0 мм рт. Считается, что нарушение цветового зрения вызывается ингибированием ФДЭ6, участвующей в процессе передачи света в сетчатой оболочке глаза. Активность силденафила в отношении ФДЭ5 более чем в 4000 раз превосходит его активность в отношении ФДЭ3, ц АМФ-специфической фосфодиэстеразы, участвующей в сокращении сердца. Силденафил не оказывает влияния на остроту зрения, восприятие контрастности, данные электроретинографии, внутриглазное давление или диаметр зрачка. Силденафил вызывает небольшое и преходящее снижение АД, которое в большинстве случаев не сопровождается клиническими симптомами. У пациентов с подтвержденной начальной возрастной дегенерацией макулы силденафил при однократном приеме в дозе 100 мг не вызывал существенных изменений зрительных функций, в частности, остроты зрения, оцениваемой с помощью решетки Амслер, способности различать цвета светофора, оцениваемые методом периметрии Хамфри, и преходящих нарушений зрительных функций, оцениваемых с помощью метода фотостресса. После приема силденафила внутрь в дозе 100 мг максимальное снижение систолического и диастолического АД в положении лежа составило в среднем 8.3 мм рт. Эффективность у взрослых пациентов с ЛГ Исследовали эффективность силденафила у 278 пациентов с первичной ЛГ (63%), ЛГ, ассоциировавшейся с диффузными заболеваниями соединительной ткани (30%), и ЛГ, развившейся после хирургического лечения врожденных пороков сердца (7%). После приема силденафила в дозе 80 мг 3 раза/сут у пациентов с системной артериальной гипертензией систолическое и диастолическое АД снижалось в среднем на 9.4 мм рт. Систолическое давление в легочной артерии снижалось в среднем на 9%. ciprofloxacin and methotrexate Also known as: Revatio The following information is NOT intended to endorse drugs or recommend therapy. When I first got 25 mg doses it didn't work for me. A lot of anxiety came with that when it came to sex and I think it just made it worse and worse (I stress pretty easily) got all the tests done on prostate, testosterone, etc. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care."I don't necessarily need this medication each time I have intercourse but when I do use it I have fantastic results. This med has worked every time and the girls I've been with, young and old, have never been let down with the erections I get with this medication. everything looked pretty good, my doctor recommended this. It varies from person to person and their medical conditions.""So I’m younger then a lot of the posts on here, but for whatever reason for the past couple years I had never been fully hard, and recently I wasn’t able to get hard at all. I took 60mg and 45 minutes in I could tell it was working. I told my wife to meet me in the room, and we had amazing sex. I came before her but was still rock hard so was able to keep going until she did (and was still hard after that) such a great feeling to be able to do that. I think I’m gonna try 40mg next time cause I probably could’ve gone 3 more times haha.

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    When a man is sexually excited, the penis rapidly fills with more blood than usual. With this extra flow of blood, the penis then expands and hardens. After the man is done having sex, this extra blood flows out of the penis back into the body. In an opposite extreme situation, if an erection lasts for a long time (more than 6 hours), it can permanently damage your penis. You should call a doctor immediately if you ever have a prolonged erection that lasts more than 4 hours. Therefore sexual activity may not be advisable for people who have heart problems. Before you start any treatment for erectile dysfunction, ask your doctor if your heart is healthy enough to handle the extra strain of having sex. If you have chest pains, dizziness or nausea during sex, stop having sex and immediately tell your doctor you have had this problem. This is called erectile dysfunction if it becomes a frequent problem. Erectile dysfunction is a serious problem that can affect both the young and the old, involving psychological causes in some cases. Among other treatments that are nowadays available for erectile dysfunction, Viagra was the first. Some conditions and medicines interfere with the natural erection process. Erectile dysfunction, defined today as the inability to attain and maintain an erect penis with sufficient rigidity for sexual intercourse, has become an increasingly common complaint that affects 140 million men worldwide. So Viagra stands out as the pioneer of drugs that treat erectile dysfunction, for twenty years. Sildenafil citrate was the first oral agent to be introduced for the treatment of erectile dysfunction, thanks to the researchers from Pfizer. Sildenafil is the active substance of Viagra, while Viagra is the commercial name. Teva’s generic Viagra has launched already in December 2017 in the United States. Risk factors for developing erectile dysfunction include age, diabetes, hypertension, obesity, lack of exercise, dyslipidemia, smoking, depression, lower urinary tract symptoms, and pelvic surgery. Sildenafil is a highly selective inhibitor of PDE type 5 and enhances NO-mediated relaxation of human corpus cavernosum. Pfizer recently started to sell the new generic version of Viagra. The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. Rare but serious adverse effects found through postmarketing surveillance include prolonged erections, severe low blood pressure, myocardial infarction (heart attack), ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects. Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose every 48 hours. blocker (typically prescribed for hypertension or for urologic conditions, such as benign prostatic hypertrophy) at the same time may lead to low blood pressure, but this effect does not occur if they are taken at least 4 hours apart.

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