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Chemical Safety Practices Recommendations. Tamoxifen Soltamox, Novadex Exposure Hazards 1 Causes uterine cancer.2 Effects fertility and may harm unborn children.3 May be passed in the milk and harm children. Response to Exposure Oral Dermal Inhalation Injection. Rinse mouth; do not induce vomiting. Report to OHS. Wash skin with soap and Activation of caspase-3 and c-Jun NH2-terminal kinase-1 signaling pathways in tamoxifen-induced apoptosis of human breast cancer cells: S. 60, 5995 (2000), Abstract; Full Text Pharmacodynamics of tamoxifen and its 4-hydroxy and N-desmethyl metabolites: activation of caspases and induction of apoptosis in rat mammary tumors and in human breast cancer cell lines: S. 60, 6601 (2000), Abstract; Full Text Antagonist effect of insulin-like growth factor I on protein kinase inhibitor-mediated apoptosis in human glioblastoma cells in association with bcl-2 and bcl-x L: S. Tamoxifen may cause cancer of the uterus (womb), strokes, and blood clots in the lungs. 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If you experience any of the following symptoms during or after your treatment, call your doctor immediately: abnormal vaginal bleeding; irregular menstrual periods; changes in vaginal discharge, especially if the discharge becomes bloody, brown, or rusty; pain or pressure in the pelvis (the stomach area below the belly button); leg swelling or tenderness; chest pain; shortness of breath; coughing up blood; sudden weakness, tingling, or numbness in your face, arm, or leg, especially on one side of your body; sudden confusion; difficulty speaking or understanding; sudden difficulty seeing in one or both eyes; sudden difficulty walking; dizziness; loss of balance or coordination; or sudden severe headache. You will need to have gynecological examinations (examinations of the female organs) regularly to find early signs of cancer of the uterus. 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